This cream is nothing sort of magical! I have used Skinceuticals day cream religiously for the past 3 years---so I was skeptical with the claims of this one. I was particularly curious about the claims made, when used in conjunction with retinoids. The studies I read were specifically about cutting the duration of irritation as your skin becomes acclimated to tret. I started tret a few months ago---worked up to 4 times a week. I have been shedding like a lizard since! This ceramide cream has all but eliminated any dryness, irritation, or flakiness I had. I have never been this impressed by a cream's effectiveness. I was about to give up on my tret journey...I am so glad I didn'tπ