Similar to Botox, Argireline works by inhibiting your nerves' ability to release a signal to your muscles, therefore limiting the movements that lead to wrinkles.. maybe that works for people who don't have a neuropathy. This solution made my eyes twitch rapidly after applying around my crow feet area!! My eye would not stop twitching for a few hours. I should have taken a video. I constantly looked like I was winking at everybody. I started to freak out, thinking it wouldn't stop. I don't have a constant twitching nerve issue. This was something new from trying out this specific product. I don't even know if it has anything to do with my nerve disorder. But that's the only time that has ever happened to me from using this product. I thought it was supposed to limit the movement of my eyes, not make them rapidly twitch!! I wonder if anyone else has had this issue...